Introduction
LactoSpore® is a commercial probiotic ingredient from the Heyndrickxia coagulans strain that produces L(+) lactic acid (previously known as Bacillus coagulans and Lactobacillus sporogenes).
The human digestive tract is home to hundreds of bacterial species that help maintain a balanced gut environment by supporting beneficial bacteria and limiting the overgrowth of less desirable microbes. Among them, lactic acid–producing bacteria are one of the most prevalent groups.
The role of lactic acid bacteria in the gut microbiome has been widely studied.
It is widely understood that these bacteria may help limit the growth of putrefactive microorganisms by:
Competitive inhibition
Creating a less favorable, more acidic environment
With the pressures of modern life, maintaining a normal, healthy, and balanced gut microbial community (eubiosis) can be challenging. Diet changes, stress, exposure to environmental pollutants, frequent travel, and shifts in weather can all place additional strain on that balance.
Research suggests that gut microbiome balance can vary from person to person, sometimes showing fewer lactic acid–producing bacteria and more undesirable microbes.
Accordingly, a practical way to support a healthy balance of gut flora is to include naturally occurring beneficial microorganisms as part of a wellness routine.
A notable spore-forming species in the lactic acid bacteria group is Heyndrickxia coagulans. Because it forms spores, it can better withstand stomach acidity; once it reaches the gut, the spores may germinate and support intestinal microbial balance, including the production of L(+) lactic acid.
Sabinsa’s LactoSpore® is a probiotic supplement designed to support overall wellness and help maintain a healthy, balanced gut microbiome.
LactoSpore® produces L(+) lactic acid isomer.
Growth conditions (in vitro):
Optimum pH Range
5.5–6.5
Temperature Range
35°C to 50°C (95 °F to 122 °F)
Choose the potency that fits your formulation. LactoSpore® is available in the following strengths:
Billion spores/g
Billion spores/g
Billion spores/g
LactoSpore® can be formulated into a wide range of delivery formats, including tablets, capsules, granules, and powders. It may also be used in gummies, confectionery (e.g., candies), and select beverages (e.g., kombucha-style drinks).
LactoSpore®-based formulations may offer the following characteristics:
High viability and stability: Can deliver a high number of viable spores, with good stability during solid-dose processing and storage. As a spore-forming probiotic, LactoSpore® is generally more heat-tolerant than non–spore-forming lactobacilli used in some formulations.
GI transit resilience: The spores are designed to tolerate challenging conditions encountered in the upper GI tract (including exposure to stomach acid and bile) and may help the probiotic reach the intestine.
Gut activity: Once in the intestine, the spores may germinate and contribute to a lactic acid–producing environment that supports microbiome balance.
Receiving FDA’s notice that it has no questions at this time regarding Sabinsa Corporation’s conclusion that its H. coagulans spore preparation is GRAS under the intended conditions of use underscores Sabinsa’s commitment to demonstrating the safety of LactoSpore®.
Even as probiotics gain unprecedented consumer acceptance, mainstream media coverage continues to highlight confusion about which strains and formats are best, which makes LactoSpore®’s well-studied, strain-specific benefits especially compelling.
